Search Results - protein+%2f+peptide

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TARGETING PRAC1 IN CASTRATION RESISTANT PROSTATE CANCER

Therapeutic peptide and biomarkers for castration-resistant prostate cancer (CRPC) Synthetic peptide targeting PRAC1 has been developed for the treatment of CRPC. Prostate cancer is an androgen dependent tumor, and the androgen receptor (AR) drives numerous mechanisms involved in disease progression. The standard therapy for metastatic...

Published: 5/15/2025 | Updated: 7/5/2024 | Inventor(s): Michael Haffner, Jin-Yih Low, Elizabeth Wasmuth, Chitvan Mittal

Keywords(s): Biomarker, Protein / Peptide, Target

Category(s): Diagnostic, Therapeutic

Widely encoded colorectal cancer-associated bacterial genes in human microbiomes

Bacterial gene-associated methods and compositions for diagnosing and treating colorectal cancer The present disclosure provides compositions and non-invasive methods for diagnosing a subject at risk for developing, or having, or at risk for progressing on colorectal cancer (CRC) based on analysis of bacterial species in the gut microbiome of the...

Published: 6/12/2024 | Updated: 6/12/2024 | Inventor(s): Neelendu Dey, Samuel Minot

Keywords(s): Bioinformatics, Biomarker, Microbiome, Protein / Peptide

Category(s): Diagnostic

Engineering B cells as a tunable source of secreted proteins

Engineering B cells to secrete select antibodies and gene products for the treatment of diseases Method to produce B cells that can provide prolonged and tunable expression of select antibodies and gene products for the treatment of diseases (for e.g., lysosomal storage diseases) Several medical disorders are caused by an insufficiency of a...

Published: 7/12/2023 | Updated: 7/12/2023 | Inventor(s): Justin Taylor, Julia McKechnie, Carson Harms

Keywords(s): Nucleic Acid, Protein / Peptide

Category(s): Cell Therapy

Panel of circulating antigens as blood-based biomarkers of colon adenoma and colon adenocarcinoma

Biomarkers for Colon Cancer Validated 5-protein panel for early detection of colon cancer and adenoma. Dr. Lampe’s laboratory has identified and validated a five protein panel for early detection of adenoma and colon cancer: BAG4, IL6ST, VWF, EGFR and glycosylated CD44. This biomarker panel has been confirmed in two independent studies...

Published: 12/6/2023 | Updated: 6/10/2021 | Inventor(s): Paul Lampe, Junghyun Rho

Keywords(s): Biomarker, Protein / Peptide

Category(s): Diagnostic

Assay relating to COVID-19

Neutalizing Monoclonal Antibodies Against SARS-CoV-2 for COVID-19 Screening and Treatment Development of neutralizing monoclonal antibodies (mAbs) that bind to the spike glycoprotein on SARS-CoV-2.The WHO declared COVID-19 a global pandemic as of March, 2020. The infection is caused by SARS-CoV-2, a beta coronavirus with 79.5% genome sequence identify...

Published: 4/18/2025 | Updated: 12/3/2020 | Inventor(s): Leonidas Stamatatos, Andrew Mcguire, Marie Pancera

Keywords(s): Protein / Peptide

Category(s): Therapeutic

Methods for HIV vaccination

Two-Step Immunization Strategy to Elicit HIV Neutralizing Antibodies Two-step immunization process guiding the maturation of VRC01-like antibodies by accommodating a conserved position of Env, which is known to restrict CD4-binding sites. VRC01-class antibodies are considered potent and broad neutralizing antibodies (bnAbs) for HIV-1 and...

Published: 5/15/2025 | Updated: 12/3/2020 | Inventor(s): Leonidas Stamatatos, Andrew Mcguire, Katherine Parks

Keywords(s): Protein / Peptide

Category(s): Vaccine

A disposable biospecimen collection system with integral refrigeration for preserving the phosphoproteome

Portable and Disposable, Single-Use Snap Freezing Device to Preserve Biospecimen Integrity Tissue freezing device to ensure biopsy samples can be rapidly frozen in a clinical or field setting. Collection and processing of high-quality tissue biopsy samples are critical steps for accurate diagnosis, monitoring, and treatment. The current...

Published: 4/16/2025 | Updated: 9/21/2020 | Inventor(s): Amanda Paulovich, Richard Ivey, Jacob Kennedy, Travis Lorentzen, Amanda Woodcock, Scott Thielman, Elijah Hooper

Keywords(s): Biomarker, Immuno Oncology, Metabolomics, Protein / Peptide

Category(s): Research Tool

Multimeric NKG2D for immunomodulation

NKG2D Biologic to Reduce Immune Cell Activation A multimeric decoy to block activation of NKG2D and treat autoimmune and inflammatory diseases, and for use in vaccine development. Dr. Roland Strong and Dr. Martin Prlic have developed a multimeric NKG2D decoy that will bind all NKG2D ligands and block the NKG2D pathway. NKG2D is a receptor...

Published: 12/27/2023 | Updated: 10/21/2019 | Inventor(s): Roland Strong, Martin Prlic, Mesfin Gewe, Thomas Spies, Veronika Groh-Spies, Peter Rupert

Keywords(s): Protein / Peptide

Category(s): Therapeutic, Vaccine

Novel Bispecific Antibody Targeting CD45

Pretargeted Radioimmunotherapy for the Treatment of of Acute Myeloid LeukemiaAn anti-CD45 bispecific antibody delivering targeted radioimmunotherapy to treat acute myeloid leukemia (AML), while avoiding systemic toxicity. Pretargeted radioimmunotherapy (PRIT) is a two-step approach that delivers radioactivity separate from the initial targeting step....

Published: 2/3/2025 | Updated: 10/25/2018 | Inventor(s): Johnnie Orozco

Keywords(s): Hybridoma / Antibody, Protein / Peptide

Category(s): Therapeutic

Rational design of alpha-helical tandem repeat proteins with closed architectures

cTRPs: Circular Tandem Repeat Protein Platform Methods to create circular tandem repeat proteins (cTRPs) to display a wide variety of functional protein domains Protein engineering is a growing field which produces new approaches to the basic study of protein structure and function as well as facilitates opportunities to produce and design novel...

Published: 2/26/2024 | Updated: 5/17/2017 | Inventor(s): Philip Bradley, Barry Stoddard

Keywords(s): Protein / Peptide

Category(s): Therapeutic, Cell Therapy

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