Search Results - roland+strong

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Selection and Use of Hematopoietic Stem Cells for Cell Transplantation and Gene Therapy Approaches Defined population predicts and quantitatively correlates with <em>in vivo</em> engraftment and multilineage potential. Hematopoietic stem cells (HSC) are the preferred target population for <em>ex vivo</em> gene therapy...

Published: 8/28/2024 | Updated: 8/28/2024 | Inventor(s): Stefan Radtke, HanS-Peter Kiem, Kurt Berckmueller, Roland Strong, Peter Rupert

Keywords(s): HSC Therapy, Lentiviral, Small Molecule, Target, Vectors

Category(s): Research Tool, Gene Therapy

NKG2D-SCD-T-Engager

Therapeutics targeting NKG2D ligands for elimination of cancer cells and senescent cells A novel fusion protein targeting NKG2D ligands for eradicating cancer and senescent cells. Natural killer group 2 member D ligands (NKG2DLs) are consistently upregulated in cancer cells, senescent cells, and cells undergoing genotoxic stress. Moreover,...

Published: 5/15/2025 | Updated: 3/10/2024 | Inventor(s): Thomas Schmitt, Roland Strong

Keywords(s): Immuno Oncology

Category(s): Therapeutic

Multimeric NKG2D for immunomodulation

NKG2D Biologic to Reduce Immune Cell Activation A multimeric decoy to block activation of NKG2D and treat autoimmune and inflammatory diseases, and for use in vaccine development. Dr. Roland Strong and Dr. Martin Prlic have developed a multimeric NKG2D decoy that will bind all NKG2D ligands and block the NKG2D pathway. NKG2D is a receptor...

Published: 12/27/2023 | Updated: 10/21/2019 | Inventor(s): Roland Strong, Martin Prlic, Mesfin Gewe, Thomas Spies, Veronika Groh-Spies, Peter Rupert

Keywords(s): Protein / Peptide

Category(s): Therapeutic, Vaccine

Multimerized HIV gp120s

Multimerized HIV gp120s for Vaccine Development An engineered HIV Env glycoprotein that improves antibody-recognition potential for HIV vaccine development. Dr. Leo Stamatatos and Dr. Roland Strong have developed a unique and promising approach to developing an effective HIV vaccine by engineering an HIV Env glycoprotein using specific...

Published: 5/15/2025 | Updated: 5/17/2017 | Inventor(s): Roland Strong, Colin Correnti, Leonidas Stamatatos, Andrew Mcguire

Keywords(s): Protein / Peptide

Category(s): Therapeutic