Search Results - nucleic+acid

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Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graftversus-host disease

bdsPredictive Immune Signatures for Chronic Graft Versus Host Disease (cGVHD) Dysregulated immune signatures may be well-suited for their ability to predict the effectiveness of agents targeting IL-17 and CSF-1. Chronic Graft Versus Host Disease (cGVHD) is the leading cause of non-relapse late morbidity and mortality following allogeneic hematopoietic...

Published: 5/2/2025 | Updated: 2/4/2025 | Inventor(s): Geoffrey Hill, Julie Boiko

Keywords(s): Biomarker, Macromolecule, Nucleic Acid

Category(s): Diagnostic

SNP panel for predicting prostate cancer-specific mortality

se; } Genomic Panel for Prediction of Metastatic-Lethal Prostate Cancer Progression Diagnostic combination panel of SNP, epigenetic, and genetic markers to identify metastatic-lethal prostate cancer. Dr. Stanford’s group has identified panels of single nucleotide polymorphisms (SNP), DNA methylation sites, and gene expression...

Published: 4/18/2025 | Updated: 12/6/2023 | Inventor(s): Janet Stanford, Ziding Feng, Elaine Ostrander

Keywords(s): Nucleic Acid

Category(s): Diagnostic

Optimized assay and efficient computational workflow to deliver same-day leukemia diagnostics

Long Range Sequencing for the Detection of Fusion Genes A CRISPR-Cas9 enrichment Nanopore sequencing assay for long-read sequencing. Fusion genes occur in 30% of AML patients, resulting in distinct types of AML. Identification of these structural variants help in diagnostic classification and drive targeted therapies. Recognition of fusion variants...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): Cecilia Yeung, Olga Sala-Torra

Keywords(s): Bioinformatics, Nucleic Acid

Category(s): Diagnostic

DNA Methylation Biomarkers for Detection of Esophageal Adenocarcinoma and High-grade Dysplasia

Novel DNA methylation biomarkers for detection of high-grade dysplasia and esophageal or junctional adenocarcinoma Minimally invasive methods and kits utilizing the methylation status of epigenetic markers that distinguish normal or Barrett’s esophageal samples from high grade dysplasia (HGD), esophageal adenocarcinoma (EAC), or junctional...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): William Grady, Ming Yu, Amber Willbanks

Keywords(s): Assay / Method, Biomarker, Nucleic Acid

Category(s): Diagnostic

Engineering B cells as a tunable source of secreted proteins

Engineering B cells to secrete select antibodies and gene products for the treatment of diseases Method to produce B cells that can provide prolonged and tunable expression of select antibodies and gene products for the treatment of diseases (for e.g., lysosomal storage diseases) Several medical disorders are caused by an insufficiency of a...

Published: 7/12/2023 | Updated: 7/12/2023 | Inventor(s): Justin Taylor, Julia McKechnie, Carson Harms

Keywords(s): Nucleic Acid, Protein / Peptide

Category(s): Cell Therapy

Bacterial Targets as Biomarkers to Predict Increased Risk for HIV Acquisition AND Bacterial Targets as Biomarkers to Diagnose Male Urethritis

Kit for Detecting and Classifying Sexually Transmitted Infections based on the Genitourinary Microbiome A test for detecting novel bacterial biomarkers for sexually transmitted infections (STIs). A growing need exists to increase the detection and surveillance of STIs, especially among adolescents and adults of reproductive age. STIs...

Published: 12/7/2023 | Updated: 9/21/2020 | Inventor(s): David Fredricks, Sujatha Srinivasan

Keywords(s): Biomarker, Microbiome, Nucleic Acid

Category(s): Diagnostic

Quantitative method for accurately counting DTCs, CTCs, and ctDNA in a biological sample – or any cell “tagged” with DNA insert

Barcoding for the Tracking and Quantification of DNASystem and methods for digital quantification and tracking of cells and DNA including, DTC, CTCs, and ctDNA.Dr. Bielas and colleagues have been working on developing methods to quantify DNA and reduce background noise to better track, sequence, and quantify DNA. Genetic constructs are created using...

Published: 7/14/2023 | Updated: 10/4/2019 | Inventor(s): Jason Bielas

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Research Tool, Therapeutic, Diagnostic

Digital quantification of random mitochondrial DNA deletions

Digital Deletion Detection and QuantiSize This method allows for measurement of rare deletions, while concurrently gathering information about size and homogeneity of the unknown template. Dr. Bielas has developed a sensitive, quantitative method to detect rare mutations in genomic and mitochondrial DNA. The main strategy is a three-step...

Published: 4/18/2025 | Updated: 2/8/2018 | Inventor(s): Jason Bielas, Sean Taylor, Matthew Laurie

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Diagnostic, Research Tool

New FSHD DUX-4-induced Candidate Biomarkers and Immune Response Regulators

Gene Expression Biomarkers to Track Facioscapulohumeral Dystrophy Disease ProgressionDUX4-dependent gene expression is a major molecular signature of Facioscapulohumeral Dystrophy (FSHD).Facioscapulohumeral dystrophy (FSHD) is a human muscular dystrophy that initially affects the muscles of the face and upper extremities, but can progress to affect...

Published: 5/5/2023 | Updated: 5/17/2017 | Inventor(s): Stephen Tapscott, Zizhen Yao, Rabi Tawil, Silvere Van Der Maarel

Keywords(s): Biomarker, Nucleic Acid

Category(s): Diagnostic