Search Results - justin+taylor

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Engineering B cells to obtain CD40 signals from antigen instead of CD40Ligand (CD40L)

Designing universal donor B cells that will respond to antigen independently of T cell boost Methods to link CD40 signaling to antigen binding independently of CD40L binding in order to potentiate B-cell responses. Vaccines increase immunity against infections by stimulating B cells to produce antibodies against the infectious agent. In addition...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): Justin Taylor, Laila Shehata, Marti Tooley

Keywords(s): HSC Therapy, Hybridoma / Antibody, Immuno Oncology

Category(s): Therapeutic

Engineering B cells as a tunable source of secreted proteins

Engineering B cells to secrete select antibodies and gene products for the treatment of diseases Method to produce B cells that can provide prolonged and tunable expression of select antibodies and gene products for the treatment of diseases (for e.g., lysosomal storage diseases) Several medical disorders are caused by an insufficiency of a...

Published: 7/12/2023 | Updated: 7/12/2023 | Inventor(s): Justin Taylor, Julia McKechnie, Carson Harms

Keywords(s): Nucleic Acid, Protein / Peptide

Category(s): Cell Therapy