Search Results - biomarker

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Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graftversus-host disease

bdsPredictive Immune Signatures for Chronic Graft Versus Host Disease (cGVHD) Dysregulated immune signatures may be well-suited for their ability to predict the effectiveness of agents targeting IL-17 and CSF-1. Chronic Graft Versus Host Disease (cGVHD) is the leading cause of non-relapse late morbidity and mortality following allogeneic hematopoietic...

Published: 5/2/2025 | Updated: 2/4/2025 | Inventor(s): Geoffrey Hill, Julie Boiko

Keywords(s): Biomarker, Macromolecule, Nucleic Acid

Category(s): Diagnostic

TARGETING PRAC1 IN CASTRATION RESISTANT PROSTATE CANCER

Therapeutic peptide and biomarkers for castration-resistant prostate cancer (CRPC) Synthetic peptide targeting PRAC1 has been developed for the treatment of CRPC. Prostate cancer is an androgen dependent tumor, and the androgen receptor (AR) drives numerous mechanisms involved in disease progression. The standard therapy for metastatic...

Published: 5/15/2025 | Updated: 7/5/2024 | Inventor(s): Michael Haffner, Jin-Yih Low, Elizabeth Wasmuth, Chitvan Mittal

Keywords(s): Biomarker, Protein / Peptide, Target

Category(s): Diagnostic, Therapeutic

Widely encoded colorectal cancer-associated bacterial genes in human microbiomes

Bacterial gene-associated methods and compositions for diagnosing and treating colorectal cancer The present disclosure provides compositions and non-invasive methods for diagnosing a subject at risk for developing, or having, or at risk for progressing on colorectal cancer (CRC) based on analysis of bacterial species in the gut microbiome of the...

Published: 6/12/2024 | Updated: 6/12/2024 | Inventor(s): Neelendu Dey, Samuel Minot

Keywords(s): Bioinformatics, Biomarker, Microbiome, Protein / Peptide

Category(s): Diagnostic

DNA Methylation Biomarkers for Detection of Esophageal Adenocarcinoma and High-grade Dysplasia

Novel DNA methylation biomarkers for detection of high-grade dysplasia and esophageal or junctional adenocarcinoma Minimally invasive methods and kits utilizing the methylation status of epigenetic markers that distinguish normal or Barrett’s esophageal samples from high grade dysplasia (HGD), esophageal adenocarcinoma (EAC), or junctional...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): William Grady, Ming Yu, Amber Willbanks

Keywords(s): Assay / Method, Biomarker, Nucleic Acid

Category(s): Diagnostic

Mesothelin directed chimeric antigen receptor T cells for treatment of acute myeloid leukemia

Mesothelin-directed CAR T Cells for the Treatment of Acute Myeloid Leukemia CAR T cells targeting mesothelin to treat Leukemia Despite maximally intensive therapy, approximately 40% of patients with acute myeloid leukemia (AML) will relapse. An effective targeted therapy is still needed to save the lives of AML patients. Through computational...

Published: 10/14/2024 | Updated: 1/20/2023 | Inventor(s): Soheil Meshinchi, Quy Le, Rhonda Ries

Keywords(s): Biomarker, Target, Vectors

Category(s): Cell Therapy

Panel of circulating antigens as blood-based biomarkers of colon adenoma and colon adenocarcinoma

Biomarkers for Colon Cancer Validated 5-protein panel for early detection of colon cancer and adenoma. Dr. Lampe’s laboratory has identified and validated a five protein panel for early detection of adenoma and colon cancer: BAG4, IL6ST, VWF, EGFR and glycosylated CD44. This biomarker panel has been confirmed in two independent studies...

Published: 12/6/2023 | Updated: 6/10/2021 | Inventor(s): Paul Lampe, Junghyun Rho

Keywords(s): Biomarker, Protein / Peptide

Category(s): Diagnostic

Endothelial activation as a biomarker of toxicity after adoptive T cell therapy

Biomarkers Predicting Risk of Cytokine Release Syndrome and Neurotoxicity Following Adoptive T Cell Therapy Risk stratification using serum-derived biomarkers to predict adverse patient responses following adoptive T cell therapies. Few assays are currently available that identify patients who are at risk of developing severe cytokine release...

Published: 2/20/2024 | Updated: 12/3/2020 | Inventor(s): Cameron Turtle, Jose Lopez, W. Conrad Liles, Stanley Riddell, David Maloney, Mark Wurfel, Dominic Chung, Junmei Chen

Keywords(s): Biomarker

Category(s): Diagnostic

Microlumenal targeting of cancer cells

Novel Method Targeting the Tumor Microenvironment as Therapeutic Treatments for Metastatic Cancers Disruption of microlumen to slow tumor growth, reduce metastasis, and increases treatment efficacy. Solid tumors and tumor cell clusters form intercellular cavities called Microlumen. These microlumen are enclosed pockets between two or...

Published: 2/4/2025 | Updated: 9/21/2020 | Inventor(s): Kevin Cheung, Emma Wrenn

Keywords(s): Biomarker, Target

Category(s): Therapeutic

Bacterial Targets as Biomarkers to Predict Increased Risk for HIV Acquisition AND Bacterial Targets as Biomarkers to Diagnose Male Urethritis

Kit for Detecting and Classifying Sexually Transmitted Infections based on the Genitourinary Microbiome A test for detecting novel bacterial biomarkers for sexually transmitted infections (STIs). A growing need exists to increase the detection and surveillance of STIs, especially among adolescents and adults of reproductive age. STIs...

Published: 12/7/2023 | Updated: 9/21/2020 | Inventor(s): David Fredricks, Sujatha Srinivasan

Keywords(s): Biomarker, Microbiome, Nucleic Acid

Category(s): Diagnostic

A disposable biospecimen collection system with integral refrigeration for preserving the phosphoproteome

Portable and Disposable, Single-Use Snap Freezing Device to Preserve Biospecimen Integrity Tissue freezing device to ensure biopsy samples can be rapidly frozen in a clinical or field setting. Collection and processing of high-quality tissue biopsy samples are critical steps for accurate diagnosis, monitoring, and treatment. The current...

Published: 4/16/2025 | Updated: 9/21/2020 | Inventor(s): Amanda Paulovich, Richard Ivey, Jacob Kennedy, Travis Lorentzen, Amanda Woodcock, Scott Thielman, Elijah Hooper

Keywords(s): Biomarker, Immuno Oncology, Metabolomics, Protein / Peptide

Category(s): Research Tool

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