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Two-Step Immunization Strategy to Elicit HIV Neutralizing Antibodies Two-step immunization process guiding the maturation of VRC01-like antibodies by accommodating a conserved position of Env, which is known to restrict CD4-binding sites. VRC01-class antibodies are considered potent and broad neutralizing antibodies (bnAbs) for HIV-1 and...

Published: 5/15/2025 | Updated: 12/3/2020 | Inventor(s): Leonidas Stamatatos, Andrew Mcguire, Katherine Parks

Keywords(s): Protein / Peptide

Category(s): Vaccine

Multimeric NKG2D for immunomodulation

NKG2D Biologic to Reduce Immune Cell Activation A multimeric decoy to block activation of NKG2D and treat autoimmune and inflammatory diseases, and for use in vaccine development. Dr. Roland Strong and Dr. Martin Prlic have developed a multimeric NKG2D decoy that will bind all NKG2D ligands and block the NKG2D pathway. NKG2D is a receptor...

Published: 12/27/2023 | Updated: 10/21/2019 | Inventor(s): Roland Strong, Martin Prlic, Mesfin Gewe, Thomas Spies, Veronika Groh-Spies, Peter Rupert

Keywords(s): Protein / Peptide

Category(s): Therapeutic, Vaccine

EBV antibodies

EBV Neutralizing Antibody and Vulnerability Site for Vaccine Design A human monoclonal antibody that neutralizes EBV infections in both B cells and epithelial cells, and new approaches to developing an EBV vaccine. Dr. McGuire and colleagues have isolated a human monoclonal antibody that binds the gH/gL protein on Epstein-Barr virus (EBV)....

Published: 2/4/2025 | Updated: 7/2/2018 | Inventor(s): Andrew Mcguire

Keywords(s): Hybridoma / Antibody

Category(s): Therapeutic, Vaccine