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Selection and Use of Hematopoietic Stem Cells for Cell Transplantation and Gene Therapy Approaches Defined population predicts and quantitatively correlates with <em>in vivo</em> engraftment and multilineage potential. Hematopoietic stem cells (HSC) are the preferred target population for <em>ex vivo</em> gene therapy...

Published: 8/28/2024 | Updated: 8/28/2024 | Inventor(s): Stefan Radtke, HanS-Peter Kiem, Kurt Berckmueller, Roland Strong, Peter Rupert

Keywords(s): HSC Therapy, Lentiviral, Small Molecule, Target, Vectors

Category(s): Research Tool, Gene Therapy

Modified Lee Symptom Scale (7-day severity)

Modified Lee Symptom Scale (7-day severity) A 30 item scale to capture the symptom burden of chronic graft-versus-host disease (cGVHD). Modifications include: 7-day recall period, response options changed from bother to severity. cGVHD adversely affects patient quality of life, functional status, and survival after allogenic hematopoietic cell...

Published: 4/16/2025 | Updated: 11/30/2023 | Inventor(s): Stephanie Lee

Keywords(s): IT / Software

Category(s): Research Tool

A disposable biospecimen collection system with integral refrigeration for preserving the phosphoproteome

Portable and Disposable, Single-Use Snap Freezing Device to Preserve Biospecimen Integrity Tissue freezing device to ensure biopsy samples can be rapidly frozen in a clinical or field setting. Collection and processing of high-quality tissue biopsy samples are critical steps for accurate diagnosis, monitoring, and treatment. The current...

Published: 4/16/2025 | Updated: 9/21/2020 | Inventor(s): Amanda Paulovich, Richard Ivey, Jacob Kennedy, Travis Lorentzen, Amanda Woodcock, Scott Thielman, Elijah Hooper

Keywords(s): Biomarker, Immuno Oncology, Metabolomics, Protein / Peptide

Category(s): Research Tool

Quantitative method for accurately counting DTCs, CTCs, and ctDNA in a biological sample – or any cell “tagged” with DNA insert

Barcoding for the Tracking and Quantification of DNASystem and methods for digital quantification and tracking of cells and DNA including, DTC, CTCs, and ctDNA.Dr. Bielas and colleagues have been working on developing methods to quantify DNA and reduce background noise to better track, sequence, and quantify DNA. Genetic constructs are created using...

Published: 7/14/2023 | Updated: 10/4/2019 | Inventor(s): Jason Bielas

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Research Tool, Therapeutic, Diagnostic

Digital quantification of random mitochondrial DNA deletions

Digital Deletion Detection and QuantiSize This method allows for measurement of rare deletions, while concurrently gathering information about size and homogeneity of the unknown template. Dr. Bielas has developed a sensitive, quantitative method to detect rare mutations in genomic and mitochondrial DNA. The main strategy is a three-step...

Published: 4/18/2025 | Updated: 2/8/2018 | Inventor(s): Jason Bielas, Sean Taylor, Matthew Laurie

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Diagnostic, Research Tool

Luteinizing hormone as a means of promoting HSC expansion ex vivo

Methods to Target Hematopoietic Stem Cells for Ablation or Expansion Luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to target and expand HSCs. Hematopoietic stem cell transplant (HCT) has been curative for many cancer malignancies and monogenetic diseases. However, current clinical limitations include...

Published: 2/4/2025 | Updated: 10/4/2017 | Inventor(s): Jarrod Dudakov, Marcel Van Den Brink, Enrico Velardi, HanS-Peter Kiem, Stefan Radtke, Scott James

Keywords(s): Assay / Method, HSC Therapy

Category(s): Cell Therapy, Research Tool, Therapeutic