Search Results - hsc+therapy

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Selection and Use of Hematopoietic Stem Cells for Cell Transplantation and Gene Therapy Approaches Defined population predicts and quantitatively correlates with <em>in vivo</em> engraftment and multilineage potential. Hematopoietic stem cells (HSC) are the preferred target population for <em>ex vivo</em> gene therapy...

Published: 8/28/2024 | Updated: 8/28/2024 | Inventor(s): Stefan Radtke, HanS-Peter Kiem, Kurt Berckmueller, Roland Strong, Peter Rupert

Keywords(s): HSC Therapy, Lentiviral, Small Molecule, Target, Vectors

Category(s): Research Tool, Gene Therapy

Human and Nonhuman Primate Hematopoietic Stem/Repopulating Cells and Methods for Enriching The Same

Published: 4/16/2025 | Updated: 8/28/2024 | Inventor(s): HanS-Peter Kiem, Jennifer Adair, Stefan Radtke

Keywords(s): HSC Therapy

Category(s): Cell Therapy, Gene Therapy

Engineering B cells to obtain CD40 signals from antigen instead of CD40Ligand (CD40L)

Designing universal donor B cells that will respond to antigen independently of T cell boost Methods to link CD40 signaling to antigen binding independently of CD40L binding in order to potentiate B-cell responses. Vaccines increase immunity against infections by stimulating B cells to produce antibodies against the infectious agent. In addition...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): Justin Taylor, Laila Shehata, Marti Tooley

Keywords(s): HSC Therapy, Hybridoma / Antibody, Immuno Oncology

Category(s): Therapeutic

Methods to Expand and Manipulate Hematopoietic Stem and Progenitor Cells

Methods to expand and manipulate hematopoietic stem and progenitor cells Culture strategies for cost effective, ex vivo expansion of hematopoietic stem and progenitor cells (HSPCs) with enhanced in vivo repopulating ability. HSPCs can be used to treat over 70 types of diseases including a variety of hematological disorders through transplantation...

Published: 10/14/2024 | Updated: 12/19/2019 | Inventor(s): Irwin Bernstein, Chengcheng Zhang, Mi Deng, Zhigang Lu, Junke Zheng

Keywords(s): HSC Therapy

Category(s): Cell Therapy

Luteinizing hormone as a means of promoting HSC expansion ex vivo

Methods to Target Hematopoietic Stem Cells for Ablation or Expansion Luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to target and expand HSCs. Hematopoietic stem cell transplant (HCT) has been curative for many cancer malignancies and monogenetic diseases. However, current clinical limitations include...

Published: 2/4/2025 | Updated: 10/4/2017 | Inventor(s): Jarrod Dudakov, Marcel Van Den Brink, Enrico Velardi, HanS-Peter Kiem, Stefan Radtke, Scott James

Keywords(s): Assay / Method, HSC Therapy

Category(s): Cell Therapy, Research Tool, Therapeutic

A Method For The Treatment Of Obesity Using Immunotherapy With Monoclonal Antibodies, Endogenous T Cells, Or T Cells Modified To Express A Chimeric Antigen Receptor Specific For The Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1)

Immunotherapy for the Treatment of Obesity A method for using immunotherapy to identify, target and eliminate fat cells. Currently, there are no treatments for obesity that directly target and eliminate fat cells (adipocytes). Dr. Stanley Riddell, in collaboration with colleagues at the NIH, have demonstrated that an anti-ROR1 CAR T is...

Published: 11/15/2023 | Updated: 5/17/2017 | Inventor(s): Stanley Riddell, Michael Hudecek, Christoph Rader

Keywords(s): HSC Therapy

Category(s): Cell Therapy, Therapeutic, Gene Therapy