Search Results - small+molecule

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Selection and Use of Hematopoietic Stem Cells for Cell Transplantation and Gene Therapy Approaches Defined population predicts and quantitatively correlates with <em>in vivo</em> engraftment and multilineage potential. Hematopoietic stem cells (HSC) are the preferred target population for <em>ex vivo</em> gene therapy...

Published: 8/28/2024 | Updated: 8/28/2024 | Inventor(s): Stefan Radtke, HanS-Peter Kiem, Kurt Berckmueller, Roland Strong, Peter Rupert

Keywords(s): HSC Therapy, Lentiviral, Small Molecule, Target, Vectors

Category(s): Research Tool, Gene Therapy

Treatment for Glioblastoma (GBM) and other brain tumors

Treatment of brain tumors with combinatorial NAMPT inhibitors and NAD precursors Methods to treat glioblastomas and other brain cancers with combinations of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and nicotinamide adenine dinucleotide (NAD) salvage pathway precursors. Treating brain tumors remain a challenging target due to challenges...

Published: 5/5/2023 | Updated: 12/3/2020 | Inventor(s): Patrick Paddison, David Hockenbery

Keywords(s): Small Molecule

Category(s): Therapeutic