Search Results - small+molecule

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Degradation of PYK2 by conjugation of PYK2 inhibitors with E3 ligase ligands and methods of use

Therapeutic small molecule degrader of FAK and PYK2 Selective PROTAC degraders of FAK and PYK2. Focal Adhesion Kinase (FAK) and Proline-Rich Tyrosine Kinase 2 (PYK2) are non-receptor tyrosine kinases that act downstream of integrins and focal adhesion complexes, linking extracellular matrix signals to intracellular signaling pathways that control...

Published: 5/18/2026 | Updated: 4/14/2026 | Inventor(s): Behnam Nabet, Baishan Jiang, Christina Kuismi, Yuan Jiang

Keywords(s): Small Molecule

Category(s): Therapeutic

Targeted delivery into CD90+ cells

Selection and Use of Hematopoietic Stem Cells for Cell Transplantation and Gene Therapy Approaches Defined population predicts and quantitatively correlates with <em>in vivo</em> engraftment and multilineage potential. Hematopoietic stem cells (HSC) are the preferred target population for <em>ex vivo</em> gene therapy...

Published: 3/20/2026 | Updated: 8/28/2024 | Inventor(s): Stefan Radtke, HanS-Peter Kiem, Kurt Berckmueller, Roland Strong, Peter Rupert

Keywords(s): HSC Therapy, Lentiviral, Small Molecule, Target, Vectors

Category(s): Research Tool, Gene Therapy

Treatment for Glioblastoma (GBM) and other brain tumors

Treatment of brain tumors with combinatorial NAMPT inhibitors and NAD precursors Methods to treat glioblastomas and other brain cancers with combinations of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and nicotinamide adenine dinucleotide (NAD) salvage pathway precursors. Treating brain tumors remain a challenging target due to challenges...

Published: 5/5/2023 | Updated: 12/3/2020 | Inventor(s): Patrick Paddison, David Hockenbery

Keywords(s): Small Molecule

Category(s): Therapeutic