Search Results - jarrod+dudakov

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NOD2 acts as a master regulator of regeneration pathways in the thymus

NOD2 Mediated Thymic Regeneration Boosts Compromised Immune Function Promotion of thymic regeneration through reduction or inhibition of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) by upregulating regenerative molecules (e.g., interleukin (IL)-22, IL-23, and bone morphogenetic protein 4 (BMP4)). As the primary...

Published: 2/4/2025 | Updated: 10/4/2019 | Inventor(s): Jarrod Dudakov, Sinéad Kinsella

Keywords(s): Target

Category(s): Therapeutic

Luteinizing hormone as a means of promoting HSC expansion ex vivo

Methods to Target Hematopoietic Stem Cells for Ablation or Expansion Luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to target and expand HSCs. Hematopoietic stem cell transplant (HCT) has been curative for many cancer malignancies and monogenetic diseases. However, current clinical limitations include...

Published: 2/4/2025 | Updated: 10/4/2017 | Inventor(s): Jarrod Dudakov, Marcel Van Den Brink, Enrico Velardi, HanS-Peter Kiem, Stefan Radtke, Scott James

Keywords(s): Assay / Method, HSC Therapy

Category(s): Cell Therapy, Research Tool, Therapeutic