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Degradation of PYK2 by conjugation of PYK2 inhibitors with E3 ligase ligands and methods of use

Therapeutic small molecule degrader of FAK and PYK2 Selective PROTAC degraders of FAK and PYK2. Focal Adhesion Kinase (FAK) and Proline-Rich Tyrosine Kinase 2 (PYK2) are non-receptor tyrosine kinases that act downstream of integrins and focal adhesion complexes, linking extracellular matrix signals to intracellular signaling pathways that control...

Published: 5/18/2026 | Updated: 4/14/2026 | Inventor(s): Behnam Nabet, Baishan Jiang, Christina Kuismi, Yuan Jiang

Keywords(s): Small Molecule

Category(s): Therapeutic