Search Results - stephen+tapscott

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Immune Modulation of DUX4 in Cancer DUX4 as predictive biomarker and therapeutic target to enhance the effectiveness of immunotherapies Although immune checkpoint blockade therapies represent important treatments for cancer, most patients are non-responders or may relapse. The efficacy of these treatments relies on cytotoxic T-cell recognition...

Published: 4/11/2025 | Updated: 2/27/2020 | Inventor(s): Stephen Tapscott, Robert Bradley, Amy Campbell, Guo-Liang Chew

Keywords(s): Biomarker, Immuno Oncology, Target

Category(s): Diagnostic

New FSHD DUX-4-induced Candidate Biomarkers and Immune Response Regulators

Gene Expression Biomarkers to Track Facioscapulohumeral Dystrophy Disease ProgressionDUX4-dependent gene expression is a major molecular signature of Facioscapulohumeral Dystrophy (FSHD).Facioscapulohumeral dystrophy (FSHD) is a human muscular dystrophy that initially affects the muscles of the face and upper extremities, but can progress to affect...

Published: 5/5/2023 | Updated: 5/17/2017 | Inventor(s): Stephen Tapscott, Zizhen Yao, Rabi Tawil, Silvere Van Der Maarel

Keywords(s): Biomarker, Nucleic Acid

Category(s): Diagnostic