Search Results - assay+%2f+method

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DNA Methylation Biomarkers for Detection of Esophageal Adenocarcinoma and High-grade Dysplasia

Novel DNA methylation biomarkers for detection of high-grade dysplasia and esophageal or junctional adenocarcinoma Minimally invasive methods and kits utilizing the methylation status of epigenetic markers that distinguish normal or Barrett’s esophageal samples from high grade dysplasia (HGD), esophageal adenocarcinoma (EAC), or junctional...

Published: 12/6/2023 | Updated: 12/6/2023 | Inventor(s): William Grady, Ming Yu, Amber Willbanks

Keywords(s): Assay / Method, Biomarker, Nucleic Acid

Category(s): Diagnostic

Acute Myeloid Leukemia Quailty of Life Questionnaire (AML-QOL)

Acute Myeloid Leukemia Quallty of Life Questionnaire (AML-QOL) A validated and reliable quality of life instrument that is specific to patients with acute myeloid leukemia. Researchers at Fred Hutchinson Cancer center has developed a novel and validated quality of life instrument specifically designed for patients with acute myeloid leukemia...

Published: 2/4/2025 | Updated: 1/24/2023 | Inventor(s): Sarah Buckley, Stephanie Lee

Keywords(s): Assay / Method

Category(s): Health IT

Random Codon Mutant Libraries Created by PCR Using Synthetic Nucleotides

Codon-Mutant Libraries of Protein-Coding Genes Technique that mutates entire genes at the codon level at a controlled rate, compared to existing error-prone PCR methods that achieve this on the nucleotide level Random mutant libraries of genes are used in a wide variety of molecular biology and bioengineering applications. Current techniques...

Published: 12/6/2023 | Updated: 10/22/2019 | Inventor(s): Jesse Bloom

Keywords(s): Assay / Method

Category(s): Therapeutic

MAIT CTLA4

MAIT Cell Immunomodulation for Targeted Treatment of Inflammatory Diseases MAIT cells undergo targeted therapeutic exploitation to alter CTLA-4 expression and dampen inflammatory responses. Mucosal-associated invariant T (MAIT) cells are non-conventional T cells that localize within inflamed tissue. Upon activation, MAIT cells act as...

Published: 12/27/2023 | Updated: 10/22/2019 | Inventor(s): Martin Prlic, Julia Berkson, Chloe Slichter

Keywords(s): Assay / Method

Category(s): Cell Therapy

Quantitative method for accurately counting DTCs, CTCs, and ctDNA in a biological sample – or any cell “tagged” with DNA insert

Barcoding for the Tracking and Quantification of DNASystem and methods for digital quantification and tracking of cells and DNA including, DTC, CTCs, and ctDNA.Dr. Bielas and colleagues have been working on developing methods to quantify DNA and reduce background noise to better track, sequence, and quantify DNA. Genetic constructs are created using...

Published: 7/14/2023 | Updated: 10/4/2019 | Inventor(s): Jason Bielas

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Research Tool, Therapeutic, Diagnostic

Digital quantification of random mitochondrial DNA deletions

Digital Deletion Detection and QuantiSize This method allows for measurement of rare deletions, while concurrently gathering information about size and homogeneity of the unknown template. Dr. Bielas has developed a sensitive, quantitative method to detect rare mutations in genomic and mitochondrial DNA. The main strategy is a three-step...

Published: 4/18/2025 | Updated: 2/8/2018 | Inventor(s): Jason Bielas, Sean Taylor, Matthew Laurie

Keywords(s): Assay / Method, Nucleic Acid

Category(s): Diagnostic, Research Tool

Luteinizing hormone as a means of promoting HSC expansion ex vivo

Methods to Target Hematopoietic Stem Cells for Ablation or Expansion Luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to target and expand HSCs. Hematopoietic stem cell transplant (HCT) has been curative for many cancer malignancies and monogenetic diseases. However, current clinical limitations include...

Published: 2/4/2025 | Updated: 10/4/2017 | Inventor(s): Jarrod Dudakov, Marcel Van Den Brink, Enrico Velardi, HanS-Peter Kiem, Stefan Radtke, Scott James

Keywords(s): Assay / Method, HSC Therapy

Category(s): Cell Therapy, Research Tool, Therapeutic