Search Results - guo-liang+chew

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Candidate T cell epitopes of short H2A histone variants (novel cancer testis antigens)

Novel Cancer/Testis Antigen: T Cell Epitopes of Short H2A Histone Variants Short H2A histone variant epitopes commonly expressed in Diffuse Large B Cell Lymphoma to be used as immunotherapy targets By analyzing data from patients with a variety of cancers, Dr. Jay Sarthy’s group at Fred Hutch Cancer Center have identified short H2A histone...

Published: 2/4/2025 | Updated: 1/25/2023 | Inventor(s): Jay Sarthy, Antoine Molaro, Marie Bleakley, Guo-Liang Chew

Keywords(s): Target

Category(s): Therapeutic

Immune Modulation of DUX4 in Cancer

Immune Modulation of DUX4 in Cancer DUX4 as predictive biomarker and therapeutic target to enhance the effectiveness of immunotherapies Although immune checkpoint blockade therapies represent important treatments for cancer, most patients are non-responders or may relapse. The efficacy of these treatments relies on cytotoxic T-cell recognition...

Published: 4/11/2025 | Updated: 2/27/2020 | Inventor(s): Stephen Tapscott, Robert Bradley, Amy Campbell, Guo-Liang Chew

Keywords(s): Biomarker, Immuno Oncology, Target

Category(s): Diagnostic