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Markers for identification and sorting of neoantigen specific CD4 T cells from solid tumors

CD4+ T cell markers, compositions, and methods for cancer therapy Markers, methods, and compositions for identifying CD4+ T cells (or T cell receptor genes thereof) with tumor antigen specificity, tumor neoantigen specificity, and/or tumor-infiltrating capacity. While cancer immunotherapies have historically focused on CD8+ T cells, tumor antigen...

Published: 12/5/2023 | Updated: 12/5/2023 | Inventor(s): Joshua Veatch, Stanley Riddell

Keywords(s): Immuno Oncology

Category(s): Cell Therapy

MHC class II restricted T cell receptors targeting mutations in EGFR

MHC class II restricted T cell receptors targeting mutations in EGFR Compositions and methods for targeting EGFR antigens (for e.g., to treat or manage cancer) Activating mutations in EGFR cause a subset of non-small cell lung cancer that occurs preferentially in women and non-smokers. EGFR mutated lung cancer responds to small molecule kinase...

Published: 12/5/2023 | Updated: 12/5/2023 | Inventor(s): Joshua Veatch, Stanley Riddell

Keywords(s): Immuno Oncology

Category(s): Cell Therapy, Therapeutic