Search Results - george+laszlo

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Development of Fully Human Anti-Human Siglec-8 Antibodies as Basis for Therapeutics to Treat Eosinophilic and Mast Cell Disorders

Novel biologics targeting Siglec-8 to treat eosinophil-driven diseases Fully human mAbs, bispecific antibodies, and NK CARs that target Siglec-8. Siglec-8 is a transmembrane protein expressed on mature eosinophils, mast cells, and (to a lesser degree) basophils. Excessive eosinophil and mast cell activity have been implicated in the pathology...

Published: 2/12/2025 | Updated: 7/18/2023 | Inventor(s): Roland Walter, George Laszlo

Keywords(s): Hybridoma / Antibody, Immuno Oncology, Target

Category(s): Therapeutic

Chimeric and Humanized Anti-CD45 Antibody for Therapeutic Applications

Chimeric and Humanized Anti-CD45 Antibody for Therapeutic Applications Humanized antibody offers reduced toxicity and anti-mouse antibody immunization CD45 is a transmembrane cell surface glycoprotein expressed on almost all hematopoietic cells and absent on non-hematopoietic cells. CD45 is an abundantly expressed target in most hematologic...

Published: 12/6/2023 | Updated: 6/9/2022 | Inventor(s): Roland Walter, Brenda Sandmaier, David King, George Laszlo

Keywords(s): Hybridoma / Antibody, Immuno Oncology, Target

Category(s): Therapeutic