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Therapeutic targeting PRAME with mTCRCAR T cells 1 in Acute Myeloid Leukemia

TCR mimic CAR T cells targeting PRAME/HLA-A2 Chimeric antigen receptor (CAR) that bind Preferentially Expressed Antigen in Melanoma (PRAME) ALYVDSLFFL (ALY) / HLA-A*0201 (HLA-A2) to treat PRAME-expressing cancers. PRAME is aberrantly expressed in childhood and adult AML and is absent in normal hematopoietic cells, providing an ideal target for...

Published: 10/14/2024 | Updated: 2/28/2023 | Inventor(s): Soheil Meshinchi, Danielle Kirkey, Anisha Loeb, Quy Le

Keywords(s): Immuno Oncology

Category(s): Therapeutic